Diadenosine tetraphosphate (Ap4A) - anE. colialarmone or a damage metabolite?

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Analogs of diadenosine tetraphosphate (Ap4A).

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Regulation of gene expression is one of several roles proposed for the stress-induced nucleotide diadenosine tetraphosphate (Ap4A). We have examined this directly by a comparative RNA-Seq analysis of KBM-7 chronic myelogenous leukemia cells and KBM-7 cells in which the NUDT2 Ap4A hydrolase gene had been disrupted (NuKO cells), causing a 175-fold increase in intracellular Ap4A. 6,288 differentia...

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This review presents our knowledge of potential biochemical conversions of minor mononucleotides, such as adenosine-5'-tetraphosphate (p4A) and adenosine-5'-pentaphosphate (p5A), and dinucleotides, such as diadenosine-5',5"'-P1,P3-triphosphate (Ap3A) and diadenosine-5',5"'-P1,P4-tetraphosphate (Ap4A), in plants. Although the occurrence of p4A, Ap3A and/or Ap4A has been demonstrated in various b...

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ژورنال

عنوان ژورنال: The FEBS Journal

سال: 2017

ISSN: 1742-464X

DOI: 10.1111/febs.14113